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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of study design that include the recruitment process and consent, adhering and the use of standard equipment.
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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. However excessive heterogeneity could cause problems with the design of the trial.
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Pragmatic trials seek to replicate real-world situations and have the highest external validity. Usually, they are requested by practitioners and policymakers in order to inform their decisions. They can also be a great method of determining the causality between an intervention and its results. However, they should not be used in lieu for explanatory trials.
The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could be used to replace explanation tests or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which prove the validity of a physiological or 프라그마틱 (https://ticketsbookmarks.com/story18010407/20-resources-to-help-You-become-more-successful-at-slot) clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study that includes recruitment, design, delivery of the intervention and follow-up.
There is a growing increase in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.