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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized by a focus on the practical aspects of the study design, including the recruitment and consent process, adherence, and the use of routinely available equipment.
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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for a pragmatic trial to be valid and reduce bias in results is also essential. However, too much heterogeneity can result in problems with the design of the trial.
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The aim of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. They are typically ordered by policymakers and practitioners to inform their decisions. They are also a good way to identify the causal relationship between the intervention and its effects. However, they shouldn't be used as a substitute for 프라그마틱 정품확인방법 explanatory studies.
The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and practice. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a practical trial that include the recruitment process, the design and implementation of the intervention, and the follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.
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